Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity
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چکیده
منابع مشابه
Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein
Expression of the HIV-1 envelope protein gp120 in brains of transgenic (tg) mice induces extensive neurodegeneration (Toggas, S. M., E. Masliah, E. M. Rockenstein, G. F. Rall, C. R. Abraham, and L. Mucke. 1994. Nature [Lond.]. 367:188-193.). To further analyze the pathogenesis of gp120-induced neurotoxicity and to assess the neuroprotective potential of human amyloid precursor proteins (hAPPs) ...
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Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades. APP is the precursor to the amyloid -protein (A ), the 38–43-amino acid residue peptide that is at the heart of the amyloid cascade hypothesis of Alzheimer disease (AD). Tremendous progress has been made since the initial identificatio...
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ژورنال
عنوان ژورنال: Molecular Neurobiology
سال: 2019
ISSN: 0893-7648,1559-1182
DOI: 10.1007/s12035-018-1460-7